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One of the most specific defense mechanisms in microorganisms is the inactivation of antimicrobial agents by β-lactamase enzymes that are capable of destroying penicillins and cephalosporins. Such a protection mechanism using Staphylococcus aureus (Staphylococcus aureus), Haemophilus influenzae (Haemophilus influenzae), Moraxella (Moraxella catarrhalis), E. coli (Escherichia coli), Klebsiella pneumoniae (Klebsiella pneumoniae), gram-negative rods Bacteroides fragilis. These are the main causative agents of infectious and inflammatory diseases of various organs and systems.Alas, the ability of microbes to resistance is progressing. So, back in 1956, Lawrence Garrod and Pamela Waterworth in the article Antibiotics versus Staphylococci Antibiotics http://canadaonpharm.com (Antibiotics versus Staphylococci) noted that one of the most important problems of modern medical practice in hospitals is the prevalence of staphylococcal antibiotic-resistant infections. However, even after half a century in this regard, little has changed: the resistance of microorganisms to antibiotics continues to be the scourge of antibiotic therapy. Researchers make a low-comforting conclusion: the formation of a number of resistant strains of pathogenic bacteria is inevitable. At the same time, some of them determined resistance to all classes of antimicrobial agents. Obviously, this not only negates all the efforts of the developers of antibacterial drugs, but also puts humanity in the face of a serious threat to become, after all, practically defenseless against a bacterial infection.